• • DRAMP ID

  • DRAMP01430

• • Peptide Name

  • Nigrocin-1-OR2 (Frogs, amphibians, animals)

• • Source

  • Odorrana andersonii (Asian frog)

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • GLISGILGVGKMLVCGLSGLC

• • Sequence Length

  • 21

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Not found

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • [Ref.22029824]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8.6 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=17.2 µg/ml);
    • Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=8.6 µg/ml);
    • Yeast: Candida albicans ATCC 2002 (MIC=8.6 µg/ml)

• • Hemolytic Activity

  • • [Ref:22029824] Not found in the literature

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Cyclic

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Cyclization (Cys15 and Cys21)

• • Nonterminal Modifications and Unusual Amino Acids

  • Disulfide bond between Cys15 and Cys21.

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP01430_predicted_structure.pdb to download.

DRAMP01430

• • Function

  • Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans.

• ·Literature 1

• • Title

  • Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs.

• • Pubmed ID

  • 22029824

• • Reference

  • J Proteome Res. 2012 Jan 1;11(1):306-319.

• • Author

  • Yang X, Lee WH, Zhang Y.