General Information

    • DRAMP ID

    • DRAMP01447

    • Peptide Name

    • Esculentin-2CHa (Frogs, amphibians, animals)

    • Source

    • Lithobates chiricahuensis

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GFSSIFRGVAKFASKGLGKDLAKLGVDLVACKISKQC

    • Sequence Length

    • 37

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacteria: E. coli (MIC=5 µM), K. pneumoniae (MIC=5 µM), P. aeruginosa (MIC=5 µM);
      • Gram-positive bacterium: S. aureus (MIC=5 µM).
      • Yeast: C. albicans (MIC=10 µM).

    • Hemolytic Activity

      • [Ref.21262304] LC50=150 µM against human erythrocytes

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Cyclization (Cys31 and Cys37)

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys31 and Cys37.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01447 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01447.

Physicochemical Information

    • Formula

    • C173H289N47O47S2

    • Absent Amino Acids

    • EHMNPTWY

    • Common Amino Acids

    • K

    • Mass

    • 3843.6

    • PI

    • 9.79

    • Basic Residues

    • 7

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 16

    • Net Charge

    • +5

    • Boman Index

    • -19.72

    • Hydrophobicity

    • 0.373

    • Aliphatic Index

    • 97.57

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 3.47

    • Polar Residues

    • 11

DRAMP01447

DRAMP01447 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Characterization of antimicrobial peptides in skin secretions from discrete populations of Lithobates chiricahuensis (Ranidae) from central and southern Arizona.

    • Reference

    • Peptides. 2011 Apr;32(4):664-669.

    • Author

    • Conlon JM, Mechkarska M, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD.