General Information

    • DRAMP ID

    • DRAMP01461

    • Peptide Name

    • Esculentin-1S (Frogs, amphibians, animals)

    • Source

    • Odorrana schmackeri (piebald odorous frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • GLFSKFAGKGIKNMIIKGIKGIGKEVGMDVIRTGIDVAGCKIKGEC

    • Sequence Length

    • 46

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus FDA 209P (MIC=3 µM);
      • Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=1.7 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Cyclization (Cys40 and Cys46)

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys40 and Cys46.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01461 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C212H364N58O58S4

    • Absent Amino Acids

    • HPQWY

    • Common Amino Acids

    • G

    • Mass

    • 4781.82

    • PI

    • 9.63

    • Basic Residues

    • 9

    • Acidic Residues

    • 4

    • Hydrophobic Residues

    • 16

    • Net Charge

    • +5

    • Boman Index

    • -20.35

    • Hydrophobicity

    • 0.254

    • Aliphatic Index

    • 99.57

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 2.78

    • Polar Residues

    • 15

DRAMP01461

DRAMP01461 chydropathy plot

Comments Information

    • Function

    • Shows antibacterial against the Gram-positive bacterium S. aureus and the Gram-negative bacterium E. coli.

Literature Information

  • ·Literature 1

    • Title

    • Cloning from tissue surrogates: antimicrobial peptide (esculentin) cDNAs from the defensive skin secretions of Chinese ranid frogs.

    • Reference

    • Genomics. 2006 May;87(5):638-644.

    • Author

    • Chen T, Zhou M, Chen W, Lorimer J, Rao P, Walker B, Shaw C.