General Information

    • DRAMP ID

    • DRAMP01480

    • Peptide Name

    • Esculentin-2CPa (Frogs, amphibians, animals)

    • Source

    • Lithobates capito (North American New World frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • GFFSLIKGVAKIATKGLAKNLGKMGLDLVGCKISKEC

    • Sequence Length

    • 37

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.19635516]Gram-negative bacterium: Escherichia coli (MIC=25 µM);
      • Gram-positive bacterium: Staphylococcus aureus (MIC=50 µM);
      • Yeast: Candida albicans (MIC=25 µM)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Cyclization (Cys31 and Cys37)

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys31 and Cys37.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01480 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C173H297N45O46S3

    • Absent Amino Acids

    • HPQRWY

    • Common Amino Acids

    • K

    • Mass

    • 3839.71

    • PI

    • 9.7

    • Basic Residues

    • 7

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 15

    • Net Charge

    • +5

    • Boman Index

    • -1.01

    • Hydrophobicity

    • 0.441

    • Aliphatic Index

    • 108.11

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 3.47

    • Polar Residues

    • 12

DRAMP01480

DRAMP01480 chydropathy plot

Comments Information

    • Function

    • Active against bacteria and fungi.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial peptides from the skin secretions of the New World frogs Lithobates capito and Lithobates warszewitschii (Ranidae).

    • Reference

    • Peptides. 2009 Oct;30(10):1775-1781.

    • Author

    • Conlon JM, Meetani MA, Coquet L, Jouenne T, Leprince J, Vaudry H, Kolodziejek J, Nowotny N, King JD.