General Information

    • DRAMP ID

    • DRAMP01486

    • Peptide Name

    • Esculentin-1GRa (Frogs, amphibians, animals)

    • Source

    • Rana grahami (Odorrana andersonii)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • GLFSKFAGKGIKNLIFKGVKHIGKEVGMDVIRTGIDVAGCKIKGEC

    • Sequence Length

    • 46

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacterium: Escherichia coli (MIC=6 µM);
      • Gram-positive bacterium: Staphylococcus aureus (MIC=12.5 µM).
      • Yeast: Candida albicans (MIC>50 µM).

    • Hemolytic Activity

      • [Ref.16621155] LC50=210 μM against human erythrocytes.

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Cyclization (Cys40 and Cys46)

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys40 and Cys46.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01486 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C219H366N60O58S3

    • Absent Amino Acids

    • PQWY

    • Common Amino Acids

    • G

    • Mass

    • 4863.86

    • PI

    • 9.63

    • Basic Residues

    • 10

    • Acidic Residues

    • 4

    • Hydrophobic Residues

    • 17

    • Net Charge

    • +6

    • Boman Index

    • -26.2

    • Hydrophobicity

    • 0.191

    • Aliphatic Index

    • 97.39

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 2.78

    • Polar Residues

    • 14

DRAMP01486

DRAMP01486 chydropathy plot

Comments Information

    • Function

    • Shows antibacterial activity, also activity against fungus C. albicans.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial peptides from diverse families isolated from the skin of the Asia frog, Rana Grahami.

    • Reference

    • Peptides 2006; 27: 2111-2117.

    • Author

    • Conlon JM, Al-Ghaferi N, Abraham B, Jiansheng H, Cosette P, Leprince J, Jouenne T, Vaudry H.