General Information
-
DRAMP ID
- DRAMP01511
-
Peptide Name
- Esculentin-2-OR5 (Frogs, amphibians, animals)
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Source
- Odorrana rotodora (Chinese odorous frog)
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Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
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Gene
- Not found
-
Sequence
- GVFTLIKGATQLIGKTLGKELGKTGLEIMACKITKQC
-
Sequence Length
- 37
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=15.8 µg/mL);
- Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=15.8 µg/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=15.8 µg/mL).
- Yeast: Candida albicans ATCC 2002 (MIC=7.9 µg/mL).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Cyclic
-
N-terminal Modification
- Free
-
C-terminal Modification
- Cyclization (Cys31 and Cys37)
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Nonterminal Modifications and Unusual Amino Acids
- Disulfide bond between Cys31 and Cys37.
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Stereochemistry
- L
-
Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP01511.
Physicochemical Information
-
Formula
- C173H303N45O49S3
Absent Amino Acids
- DHNPRSWY
Common Amino Acids
- GK
Mass
- 3893.76
PI
- 9.51
Basic Residues
- 6
Acidic Residues
- 2
Hydrophobic Residues
- 13
Net Charge
- +4
-
Boman Index
- -5.38
Hydrophobicity
- 0.303
Aliphatic Index
- 108.11
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 3.47
Polar Residues
- 13
DRAMP01511
Comments Information
Function
- Shows antibacterial activity against both Gram-positive and Gram-negative bacteria and against the fungus C. albicans.
Literature Information
- ·Literature 1
-
Title
- Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs.
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Pubmed ID
- 22029824
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Reference
- J Proteome Res. 2012 Jan 1;11(1):306-319.
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Author
- Yang X, Lee WH, Zhang Y.