General Information

    • DRAMP ID

    • DRAMP01705

    • Peptide Name

    • Dermaseptin-like peptide (SmDLP; Frogs, amphibians, animals)

    • Source

    • Schistosoma mansoni (Blood fluke)

    • Family

    • Belongs to the frog skin active peptide family (Dermaseptin subfamily)

    • Gene

    • Not found

    • Sequence

    • DLWNSIKDMAAAAGRAALNAVTGMVNQ

    • Sequence Length

    • 27

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • [Swiss_Prot Entry P83914]Gram-positive bacterium: Micrococcus luteus;
      • Yeast: Candida albicans.

    • Hemolytic Activity

      • [Ref:6539015]Show hemolytic activity on human and duck erythrocytes

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01705 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01705.

Physicochemical Information

    • Formula

    • C118H194N36O38S2

    • Absent Amino Acids

    • CEFHPY

    • Common Amino Acids

    • A

    • Mass

    • 2789.18

    • PI

    • 5.96

    • Basic Residues

    • 2

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 13

    • Net Charge

    • 0

    • Boman Index

    • -24.92

    • Hydrophobicity

    • 0.159

    • Aliphatic Index

    • 90.74

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 211.54

    • Polar Residues

    • 7

DRAMP01705

DRAMP01705 chydropathy plot

Comments Information

    • Has hemolytic activity on human and duck erythrocytes.

Literature Information

  • ·Literature 1

    • Title

    • Schistosoma mansoni dermaseptin-like peptide: structural and functional characterization.

    • Reference

    • J Parasitol. 2005 Dec;91(6):1340-1351.

    • Author

    • Quinn GA, Heymans R, Rondaj F, Shaw C, de Jong-Brink M.