General Information

    • DRAMP ID

    • DRAMP01820

    • Peptide Name

    • Temporin-1Cb (Temporin 1Cb; Frogs, amphibians, animals)

    • Source

    • Rana clamitans (Green frog) (Lithobates clamitans)

    • Family

    • Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.

    • Gene

    • Not found

    • Sequence

    • FLPLFASLIGKLL

    • Sequence Length

    • 13

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • [Ref.10822101] Gram-positive bacterium: Staphylococcus aureus (MIC=140 μM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01820 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01820.

Physicochemical Information

    • Formula

    • C73H118N14O15

    • Absent Amino Acids

    • CDEHMNQRTVWY

    • Common Amino Acids

    • L

    • Mass

    • 1431.82

    • PI

    • 8.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +1

    • Boman Index

    • 29.28

    • Hydrophobicity

    • 1.862

    • Aliphatic Index

    • 187.69

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP01820

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacterium Staphylococcus aureus.

    • Tissue specificity

    • Expressed by the skin glands.

Literature Information

  • ·Literature 1

    • Title

    • Purification and characterization of antimicrobial peptides from the skin of the North American green frog Rana clamitans.

    • Reference

    • Peptides. 2000 Apr;21(4):469-476.

    • Author

    • Halverson T, Basir YJ, Knoop FC, Conlon JM.