General Information

    • DRAMP ID

    • DRAMP01880

    • Peptide Name

    • Brevinin-2LTb (Frogs, amphibians, animals)

    • Source

    • Hylarana latouchii (Broad-folded frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • SILDKIKNVALGVARGAGTGILKALLCKLDKSC

    • Sequence Length

    • 33

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria:
        Target OrganismActivity
        Staphylococcus aureus ATCC2592MIC=3.8 µM
        Bacillus licheniformis X39MIC=3.8 µM
        Staphylococcus carnosus KHSMIC=1.9 µM
        Rhodococcus rhodochrous X15 (MIC=1.9 µM);-
      • Gram-negative bacteria:
        Target OrganismActivity
        Escherichia coli ATCC25922MIC=30 µM
        Serratia rubidaea X01MIC=60 µM
        Pseudomonas aeruginosa 1.50MIC=30 µM
        Psychrobacter faecalis X29MIC=1.9 µM

    • Hemolytic Activity

      • [Ref.22426384] LD50=480 μM against human erythrocytes

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Cyclization (Cys27 and Cys33)

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys27 and Cys33.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01880 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01880.

Physicochemical Information

    • Formula

    • C148H266N42O42S2

    • Absent Amino Acids

    • EFHMPQWY

    • Common Amino Acids

    • L

    • Mass

    • 3370.12

    • PI

    • 9.59

    • Basic Residues

    • 6

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 15

    • Net Charge

    • +4

    • Boman Index

    • -10.2

    • Hydrophobicity

    • 0.561

    • Aliphatic Index

    • 136.06

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 3.91

    • Polar Residues

    • 10

DRAMP01880

DRAMP01880 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii.

    • Reference

    • Biochimie. 2012 Jun;94(6):1317-1326.

    • Author

    • Wang H, Yu Z, Hu Y, Yu H, Ran R, Xia J, Wang D, Yang S, Yang X, Liu J.