General Information
-
DRAMP ID
- DRAMP02332
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Peptide Name
- Piscidin-3 (Pis-3; fish, chordates, animals)
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Source
- Morone chrysops x Morone saxatilis (white bass x striped sea-bass)
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Family
- Belongs to the pleurocidin family
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Gene
- Not found
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Sequence
- FIHHIFRGIVHAGRSIGRFLTG
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Sequence Length
- 22
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UniProt Entry
- P0C006
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral
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Target Organism
- [Swiss_Prot Entry P0C006]broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria
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Hemolytic Activity
-
- [Ref.11713517]5% hemolytic activity at 100 μg/mL against human erythrocytes
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
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PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP02332.
Physicochemical Information
-
Formula
- C116H179N37O25
Absent Amino Acids
- CDEKMNPQWY
Common Amino Acids
- GI
Mass
- 2491.93
PI
- 12.3
Basic Residues
- 6
Acidic Residues
- 0
Hydrophobic Residues
- 10
Net Charge
- +6
-
Boman Index
- -21.56
Hydrophobicity
- 0.455
Aliphatic Index
- 106.36
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 6
DRAMP02332
Comments Information
Function
- Exhibits broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria. Has hemolytic activity.
Tissue specificity
- Mast cells in gill, skin and gut, and in lining blood vessels in the viscera.
Literature Information
- ·Literature 1
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Title
- Peptide antibiotics in mast cells of fish.
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Pubmed ID
- 11713517
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Reference
- Nature. 2001 Nov 15;414(6861):268-269.
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Author
- Silphaduang U, Noga EJ.