• DRAMP ID

    • DRAMP02332
    • Peptide Name

    • Piscidin-3 (Pis-3; fish, chordates, animals)
    • Source

    • Morone chrysops x Morone saxatilis (white bass x striped sea-bass)
    • Family

    • Belongs to the pleurocidin family
    • Gene

    • Not found
    • Sequence

    • FIHHIFRGIVHAGRSIGRFLTG
    • Sequence Length

    • 22
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral
    • Target Organism

    • [Swiss_Prot Entry P0C006]broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria
    • Hemolytic Activity

      • [Ref.11713517]5% hemolytic activity at 100 μg/mL against human erythrocytes
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02332 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP02332.
    • Formula

    • C116H179N37O25
    • Absent Amino Acids

    • CDEKMNPQWY
    • Common Amino Acids

    • GI
    • Mass

    • 2491.93
    • PI

    • 12.3
    • Basic Residues

    • 6
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 10
    • Net Charge

    • +6
    • Boman Index

    • -21.56
    • Hydrophobicity

    • 0.455
    • Aliphatic Index

    • 106.36
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 6

DRAMP02332

DRAMP02332 chydropathy plot
    • Function

    • Exhibits broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria. Has hemolytic activity.
    • Tissue specificity

    • Mast cells in gill, skin and gut, and in lining blood vessels in the viscera.
  • ·Literature 1
    • Title

    • Peptide antibiotics in mast cells of fish.
    • Reference

    • Nature. 2001 Nov 15;414(6861):268-269.
    • Author

    • Silphaduang U, Noga EJ.