• • DRAMP ID

  • DRAMP02353

• • Peptide Name

  • Pleurocidin-like peptide WFX (fish, chordates, animals; Predicted)

• • Source

  • Pseudopleuronectes americanus (Winter flounder) (Pleuronectes americanus)

• • Family

  • Not found

• • Gene

  • ple6

• • Sequence

  • RSTEDIIKSISGGGFLNAMNA

• • Sequence Length

  • 21

• • UniProt Entry

  • Q7T053

• • Protein Existence

  • Predicted

• • Biological Activity

  • Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • Gram-negative bacteria: Aeromonas salmonicida A449 field isolate (MIC>64 µg/ml), A. salmonicida 97-4 field isolate (MIC>64 µg/ml), Pseudomonas aeruginosa K799 (MIC>64 µg/ml), Pseudomonas aeruginosa Z61 (MIC>64 µg/ml), Escherichia coli (MIC>64 µg/ml), Salmonella typhimurium 14028s (MIC>64 µg/ml), S. typhimurium MS7953s (MIC>64 µg/ml);
    • Gram-positive bacteria: Staphylococcus epidermidis (human clinical isolates) (MIC>64 µg/ml), Staphylococcus aureus (MRSA) (MIC>64 µg/ml).
    • Fungi: Candida albica (MIC>64 µg/ml).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP02353.

DRAMP02353

• • Function

  • Has antibacterial and antifungal activity.

• ·Literature 1

• • Title

  • Identification, structure and differential expression of novel pleurocidins clustered on the genome of the winter flounder, Pseudopleuronectes americanus (Walbaum).

• • Pubmed ID

  • 12950255

• • Reference

  • Eur J Biochem. 2003 Sep;270(18):3720-3730.

• • Author

  • Douglas SE, Patrzykat A, Pytyck J, Gallant JW.