General Information

    • DRAMP ID

    • DRAMP02455

    • Peptide Name

    • L-amino-acid oxidase (ACL-LAO; LAAO; LAO)

    • Source

    • Agkistrodon contortrix laticinctus (Broad-banded copperhead)(Agkistrodon mokasen laticinctus)

    • Family

    • Belongs to the flavin monoamine oxidase family (FIG1 subfamily)

    • Gene

    • Not found

    • Sequence

    • ADSRNPLEEEFRETNYEEF

    • Sequence Length

    • 19

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antiparasitic

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02455 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02455.

Physicochemical Information

    • Formula

    • C102H147N27O39

    • Absent Amino Acids

    • CGHIKMQVW

    • Common Amino Acids

    • E

    • Mass

    • 2375.45

    • PI

    • 4.06

    • Basic Residues

    • 2

    • Acidic Residues

    • 7

    • Hydrophobic Residues

    • 4

    • Net Charge

    • -5

    • Boman Index

    • -86.12

    • Hydrophobicity

    • -1.774

    • Aliphatic Index

    • 25.79

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 82.78

    • Polar Residues

    • 5

DRAMP02455

DRAMP02455 chydropathy plot

Comments Information

    • Function

    • Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids (L-Ile followed by L-Phe, L-Met, L-Val, L-Arg, L-Leu), thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage (minimum hemorrhagic dose of 10 µg), and apoptosis. May also induce hemolysis, edema, antibacterial and antiparasitic activities. May also regulate platelet aggregation. Effects of snake L-amino oxidases on platelets are controversial, since they either induce aggregation or inhibit agonist-induced aggregation. These different effects are probably due to different experimental conditions.

    • Tissue specificity

    • Expressed by the venom gland.

Literature Information

  • ·Literature 1

    • Title

    • Isolation and structural characterization of a cytotoxic L-amino acid oxidase from Agkistrodon contortrix laticinctus snake venom: preliminary crystallographic data.

    • Reference

    • Arch Biochem Biophys. 1999 Aug 15;368(2):285-290.

    • Author

    • Souza DH, Eugenio LM, Fletcher JE, Jiang MS, Garratt RC, Oliva G, Selistre-de-Araujo HS.