General Information

    • DRAMP ID

    • DRAMP02461

    • Peptide Name

    • L-amino-acid oxidase (BmarLAAO; LAAO; LAO; snakes, reptils, animals)

    • Source

    • Bothrops marajoensis (Marajo lancehead)

    • Family

    • Belongs to the flavin monoamine oxidase family (FIG1 subfamily)

    • Gene

    • Not found

    • Sequence

    • AHDGNPLEECFREDDEEFFLEIAKNGLTATSNPKRVVIV

    • Sequence Length

    • 39

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal, Antiparasitic

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02461 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02461.

Physicochemical Information

    • Formula

    • C193H300N52O64S

    • Absent Amino Acids

    • MQWY

    • Common Amino Acids

    • E

    • Mass

    • 4404.88

    • PI

    • 4.44

    • Basic Residues

    • 5

    • Acidic Residues

    • 9

    • Hydrophobic Residues

    • 14

    • Net Charge

    • -4

    • Boman Index

    • -86.83

    • Hydrophobicity

    • -0.485

    • Aliphatic Index

    • 80

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 9

DRAMP02461

DRAMP02461 chydropathy plot

Comments Information

    • Function

    • Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, apoptosis of vascular endothelial cells or tumor cell lines, and antiparasitic activities, as well as regulation of platelet aggregation. Effects of snake L-amino oxidases on platelets are controversial, since they either induce aggregation or inhibit agonist-induced aggregation. These different effects are probably due to different experimental conditions By similarity. In addition, this protein inhibits dose-dependently the growth of Gram-positive, Gram-negative bacteria and yeast, probably by the generation of hydrogen peroxide.

    • Tissue specificity

    • Expressed by the venom gland.

    • Miscellaneous

    • Has parasiticidal activities against leishmania, as a result of enzyme-catalyzed hydrogen peroxide production.

Literature Information

  • ·Literature 1

    • Title

    • Antibacterial and antiparasitic effects of Bothrops marajoensis venom and its fractions: phospholipase A2 and L-amino acid oxidase.

    • Reference

    • Toxicon. 2010 Apr 1;55(4):795-804.

    • Author

    • Costa Torres AF, Dantas RT, Toyama MH, Diz Filho E, Zara FJ, Rodrigues de Queiroz MG, Pinto Nogueira NA, Rosa de Oliveira M, de Oliveira Toyama D, Monteiro HS, Martins AM.