General Information
-
DRAMP ID
- DRAMP02534
-
Peptide Name
- CRISPR-associated endoribonuclease Cas2 2 (Antiviral defensin)
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Source
- Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630/ NBRC 100827)
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Family
- Belongs to the CRISPR-associated endoribonuclease Cas2 prote
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Gene
- cas2-2
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Sequence
- MYVVVAYDITEDEVRNKVADALKAYGLERIQRSVFVGRINPALLKDLVERLKRITKGANADITIFKVDRRAIDTAIRIGPPPPARKNVDLY
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Sequence Length
- 91
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UniProt Entry
- Q8ZZL9
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Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial, Antiviral
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Metal-binding
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP02534.
Physicochemical Information
-
Formula
- C462H765N133O130S
Absent Amino Acids
- CHW
Common Amino Acids
- ARVI
Mass
- 10295.03
PI
- 9.75
Basic Residues
- 17
Acidic Residues
- 12
Hydrophobic Residues
- 38
Net Charge
- +5
-
Boman Index
- -182.1
Hydrophobicity
- -0.171
Aliphatic Index
- 111.43
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5960
Absorbance 280nm
- 66.22
Polar Residues
- 17
DRAMP02534
Comments Information
Function
- CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity).
Literature Information
- ·Literature 1
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Title
- Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum.
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Pubmed ID
- 11792869
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Reference
- Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):984-989.
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Author
- Fitz-Gibbon ST, Ladner H, Kim UJ, Stetter KO, Simon MI, Miller JH.