• DRAMP ID

    • DRAMP02534
    • Peptide Name

    • CRISPR-associated endoribonuclease Cas2 2 (Antiviral defensin)
    • Source

    • Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630/ NBRC 100827)
    • Family

    • Belongs to the CRISPR-associated endoribonuclease Cas2 prote
    • Gene

    • cas2-2
    • Sequence

    • MYVVVAYDITEDEVRNKVADALKAYGLERIQRSVFVGRINPALLKDLVERLKRITKGANADITIFKVDRRAIDTAIRIGPPPPARKNVDLY
    • Sequence Length

    • 91
    • Protein Existence

    • Homology
    • Biological Activity

    • Antimicrobial, Antiviral
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Metal-binding
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP02534 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP02534.
    • Formula

    • C462H765N133O130S
    • Absent Amino Acids

    • CHW
    • Common Amino Acids

    • ARVI
    • Mass

    • 10295.03
    • PI

    • 9.75
    • Basic Residues

    • 17
    • Acidic Residues

    • 12
    • Hydrophobic Residues

    • 38
    • Net Charge

    • +5
    • Boman Index

    • -182.1
    • Hydrophobicity

    • -0.171
    • Aliphatic Index

    • 111.43
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5960
    • Absorbance 280nm

    • 66.22
    • Polar Residues

    • 17

DRAMP02534

DRAMP02534 chydropathy plot
    • Function

    • CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity).
  • ·Literature 1
    • Title

    • Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum.
    • Reference

    • Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):984-989.
    • Author

    • Fitz-Gibbon ST, Ladner H, Kim UJ, Stetter KO, Simon MI, Miller JH.