General Information

    • DRAMP ID

    • DRAMP02772

    • Peptide Name

    • Pilosulin-3a (Allergen Myr p II; Pilosulin-2; ants, insects, animals)

    • Source

    • Myrmecia pilosula (Jack jumper ant) (Australian jumper ant)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • IDWKKVDWKKVSKKTCKVMLKACKFL

    • Sequence Length

    • 26

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • [Ref.15639237]15% hemolytic activity at 10 μM, 40% hemolytic activity at 100 μM against human erythrocytes.

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • IgE

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02772 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02772.

Physicochemical Information

    • Formula

    • C147H245N37O33S3

    • Absent Amino Acids

    • EGHNPQRY

    • Common Amino Acids

    • K

    • Mass

    • 3154.97

    • PI

    • 9.94

    • Basic Residues

    • 9

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +7

    • Boman Index

    • -32.12

    • Hydrophobicity

    • -0.354

    • Aliphatic Index

    • 82.31

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 11125

    • Absorbance 280nm

    • 445

    • Polar Residues

    • 4

DRAMP02772

DRAMP02772 chydropathy plot

Comments Information

    • Function

    • Has hemolytic activity.

    • Tissue specificity

    • Expressed by the venom gland.

    • Allergenic properties

    • Causes an allergic reaction in human.

    • PTM

    • Contains one disulfide bond and C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • Characterisation of major peptides in 'jack jumper' ant venom by mass spectrometry.

    • Reference

    • Toxicon. 2004 Feb;43(2):173-183.

    • Author

    • Davies NW, Wiese MD, Brown SG.
  • ·Literature 2

    • Title

    • Expression of jumper ant (Myrmecia pilosula) venom allergens: post-translational processing of allergen gene products.

    • Reference

    • Biochem Mol Biol Int. 1996 Aug;39(5):877-885.

    • Author

    • Donovan GR, Street MD, Tetaz T, Smith AI, Alewood D, Alewood P, Sutherland SK, Baldo BA.