General Information

    • DRAMP ID

    • DRAMP02782

    • Peptide Name

    • Defensin, isoforms B and C (Insects, animals)

    • Source

    • Zophobas atratus (Giant mealworm beetle)

    • Family

    • Belongs to the invertebrate defensin family (Type 1 subfamily)

    • Gene

    • Not found

    • Sequence

    • FTCDVLGFEIAGTKLNSAACGAHCLALGRRGGYCNSKSVCVCR

    • Sequence Length

    • 43

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02782 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02782.

Physicochemical Information

    • Formula

    • C187H304N58O56S6

    • Absent Amino Acids

    • MPQW

    • Common Amino Acids

    • CG

    • Mass

    • 4453.19

    • PI

    • 8.68

    • Basic Residues

    • 6

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 15

    • Net Charge

    • +4

    • Boman Index

    • -39.76

    • Hydrophobicity

    • 0.37

    • Aliphatic Index

    • 77.21

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1865

    • Absorbance 280nm

    • 44.4

    • Polar Residues

    • 20

DRAMP02782

DRAMP02782 chydropathy plot

Comments Information

    • Function

    • Involved in anti Gram-positive activity of immune hemolymph of Z. atratus.

Literature Information

  • ·Literature 1

    • Title

    • Insect immunity. Isolation from a coleopteran insect of a novel inducible antibacterial peptide and of new members of the insect defensin family.

    • Reference

    • J Biol Chem. 1991 Dec 25;266(36):24520-24525.

    • Author

    • Bulet P, Cociancich S, Dimarcq JL, Lambert J, Reichhart JM, Hoffmann D, Hetru C, Hoffmann JA.