General Information
-
DRAMP ID
- DRAMP02816
-
Peptide Name
- Lumbrican
-
Source
- Lumbricus rubellus (humus earthworm)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- RQKDKRPYSERKNQYTGPQFLYPPERIPP
-
Sequence Length
- 29
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Antifungal, Anti-Gram+, Anti-Gram-
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Target Organism
-
- Gram-positive bacteria: Bacillus subtilis ATCC 62037, Staphylococcus aureus ATCC 15752, Streptococcus mutans ATCC 25175;
- Gram-negative bacteria: Escherichia coli ATCC 27325, Pseudomonas putida ATCC 17426, Serratia sp. ATCC 21074.
- Fungi: Candida albicans ATCC 10231, Cryptococcus neoformans ATCC 34881, Saccharomyces cerevisiae ATCC 44774.
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP02816.
Physicochemical Information
-
Formula
- C162H250N48O45
Absent Amino Acids
- ACHMVW
Common Amino Acids
- P
Mass
- 3590.06
PI
- 9.99
Basic Residues
- 7
Acidic Residues
- 3
Hydrophobic Residues
- 3
Net Charge
- +4
-
Boman Index
- -114.56
Hydrophobicity
- -2.017
Aliphatic Index
- 26.9
Half Life
-
- Mammalian:1 hour
- Yeast:2 min
- E.coli:2 min
Extinction Coefficient Cystines
- 4470
Absorbance 280nm
- 159.64
Polar Residues
- 7
DRAMP02816
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
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Title
- Lumbricin I, a novel proline-rich antimicrobial peptide from the earthworm: purification, cDNA cloning and molecular characterization.
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Pubmed ID
- 9784609
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Reference
- Biochim Biophys Acta. 1998 Oct 22;1408(1):67-76.
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Author
- Cho JH, Park CB, Yoon YG, Kim SC.