General Information

    • DRAMP ID

    • DRAMP02822

    • Peptide Name

    • Holotricin-3 (Gly-rich; His-rich; invertebrate defensin; animals)

    • Source

    • Holotrichia diomphalia (Korean black chafer)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • YGPGDGHGGGHGGGHGGGHGNGQGGGHGHGPGGGFGGGHGGGHGGGGRGGGGSGGGGSPGHGAGGGYPGGHGGGHHGGYQTHGY

    • Sequence Length

    • 84

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • Yeast: Candida ablicans.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02822 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02822.

Physicochemical Information

    • Formula

    • C286H386N116O97

    • Absent Amino Acids

    • CEIKLMVW

    • Common Amino Acids

    • G

    • Mass

    • 7000.93

    • PI

    • 7.41

    • Basic Residues

    • 14

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 2

    • Net Charge

    • +13

    • Boman Index

    • -57.26

    • Hydrophobicity

    • -1.079

    • Aliphatic Index

    • 1.19

    • Half Life

      • Mammalian:2.8 hour
      • Yeast:10 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5960

    • Absorbance 280nm

    • 71.81

    • Polar Residues

    • 61

DRAMP02822

DRAMP02822 chydropathy plot

Comments Information

    • Function

    • Has antifungal activity against C. albicans.

Literature Information

  • ·Literature 1

    • Title

    • Purification and cDNA cloning of an antifungal protein from the hemolymph of Holotrichia diomphalia larvae.

    • Reference

    • Biol. Pharm. Bull. 1995; 18:1049-1052.

    • Author

    • Lee S.Y, Moon H.J, Kurata S, Natori S, Lee B.L.