General Information

    • DRAMP ID

    • DRAMP02856

    • Peptide Name

    • Cathelicidin-7 (Antibacterial peptide BMAP-34; mammals, animals)

    • Source

    • Bos taurus (Bovine)

    • Family

    • Belongs to the cathelicidin family

    • Gene

    • CATHL7

    • Sequence

    • AGLFRRLRDSIRRGQQKILEKARRIGERIKDIFR

    • Sequence Length

    • 34

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02856 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02856.

Physicochemical Information

    • Formula

    • C181H316N66O46

    • Absent Amino Acids

    • CHMNPTVWY

    • Common Amino Acids

    • R

    • Mass

    • 4152.91

    • PI

    • 11.91

    • Basic Residues

    • 12

    • Acidic Residues

    • 4

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +8

    • Boman Index

    • -144.71

    • Hydrophobicity

    • -0.944

    • Aliphatic Index

    • 97.65

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP02856

DRAMP02856 chydropathy plot

Comments Information

    • Function

    • Exerts a potent antimicrobial activity.

    • Tissue specificity

    • Expressed in bone marrow myeloid cells, spleen and testis.

Literature Information

  • ·Literature 1

    • Title

    • Structural organization of the bovine cathelicidin gene family and identification of a novel member.

    • Reference

    • FEBS Lett. 1997 Nov 17;417(3):311-315.

    • Author

    • Scocchi M, Wang S, Zanetti M.
  • ·Literature 2

    • Title

    • Sequence analysis and polymorphism discovery in 4 members of the bovine cathelicidin gene family.

    • Reference

    • J Hered. 2009 Mar-Apr;100(2):241-245.

    • Author

    • Gillenwaters EN, Seabury CM, Elliott JS, Womack JE.