General Information

    • DRAMP ID

    • DRAMP02874

    • Peptide Name

    • Chromacin (mammals, animals)

    • Source

    • Bos taurus (Bovine)

    • Family

    • Belongs to the chromogranin/secretogranin protein family

    • Gene

    • CHGA

    • Sequence

    • YPGPQAKEDSEGPSQGPASREK

    • Sequence Length

    • 22

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacterium: Micrococcus luteus.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Binds calcium with a low-affinity.

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP02874 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP02874.

Physicochemical Information

    • Formula

    • C97H151N29O37

    • Absent Amino Acids

    • CFHILMNTVW

    • Common Amino Acids

    • P

    • Mass

    • 2315.44

    • PI

    • 4.87

    • Basic Residues

    • 3

    • Acidic Residues

    • 4

    • Hydrophobic Residues

    • 2

    • Net Charge

    • -1

    • Boman Index

    • -70.15

    • Hydrophobicity

    • -1.864

    • Aliphatic Index

    • 9.09

    • Half Life

      • Mammalian:2.8 hour
      • Yeast:10 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 70.95

    • Polar Residues

    • 7

DRAMP02874

DRAMP02874 chydropathy plot

Comments Information

    • Function

    • Has antibacterial activity against the Gram-positive bacterium M. luteus.

Literature Information

  • ·Literature 1

    • Title

    • Antibacterial activity of glycosylated and phosphorylated chromogranin A-derived peptide 173-194 from bovine adrenal medullary chromaffin granules.

    • Reference

    • J Biol Chem. 1996 Nov 8;271(45):28533-28540.

    • Author

    • Strub JM, Goumon Y, Lugardon K, Capon C, Lopez M, Moniatte M, van Dorsselaer A, Aunis D, Metz-Boutigue MH.