General Information
-
DRAMP ID
- DRAMP02985
-
Peptide Name
- Neutrophil cationic peptide 2 (CP-2; GNCP-2; pigs, mammals, animals)
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Source
- Cavia porcellus (Guinea pig)
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Family
- Belongs to the alpha-defensin family
-
Gene
- Not found
-
Sequence
- RRCICTTRTCRFPYRRLGTCLFQNRVYTFCC
-
Sequence Length
- 31
-
Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral
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Target Organism
-
- Gram-negative bacterium: Escherichia coli;
- Gram-positive bacterium: Staphylococcus aureus.
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
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Structure
- Bridge
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP02985.
Physicochemical Information
-
Formula
- C164H262N54O41S6
Absent Amino Acids
- ADEHKMSW
Common Amino Acids
- R
Mass
- 3838.58
PI
- 9.8
Basic Residues
- 7
Acidic Residues
- 0
Hydrophobic Residues
- 7
Net Charge
- +7
-
Boman Index
- -93.39
Hydrophobicity
- -0.223
Aliphatic Index
- 47.1
Half Life
-
- Mammalian:1 hour
- Yeast:2 min
- E.coli:2 min
Extinction Coefficient Cystines
- 3355
Absorbance 280nm
- 111.83
Polar Residues
- 15
DRAMP02985
Comments Information
Function
- Has antibiotic, anti-fungi and antiviral activity.
PTM
- Contains three disulfide bonds (By similarity).
Literature Information
- ·Literature 1
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Title
- Cloning and characterization of the guinea pig neutrophil cationic peptide-1 and -2 genes.
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Pubmed ID
- 8173076
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Reference
- DNA Seq. 1993;4(2):123-128.
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Author
- Nagaoka I, Nonoguchi A, Yamashita T.
- ·Literature 2
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Title
- Synergistic actions of antibacterial neutrophil defensins and cathelicidins.
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Pubmed ID
- 10738945
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Reference
- Inflamm Res. 2000 Feb;49(2):73-79.
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Author
- Nagaoka I, Hirota S, Yomogida S, Ohwada A, Hirata M.