• • DRAMP ID

  • DRAMP02997

• • Peptide Name

  • Apidaecin-1B (Apidaecin IB; Insects, animals)

• • Source

  • Apis mellifera (Honeybee)

• • Family

  • Belongs to the apidaecin family

• • Gene

  • Not found

• • Sequence

  • GNNRPVYIPQPRPPHPRL

• • Sequence Length

  • 18

• • UniProt Entry

  • P35581,Q06602,Q06601,Q8WSY8

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.2676519] Gram-negative bacteria: Agrobacterium tumefaciens (MIC=0.2 μg/ml), Erwinia salicis (MIC=0.02 μg/ml), Escherichia coli (MIC=0.1 μg/ml), Pseudomonas syringae (MIC=0.1 μg/ml), Rhizobium meliloti (MIC=0.02 μg/ml), Salmonella Newport (MIC=0.2 μg/ml), Salmonella typhimurium (MIC=0.1 μg/ml), Shigella flexneri (MIC=0.1 μg/ml);
    • Gram-positive bacteria: Corynebacterium insidiosum (MIC=50 μg/ml), Bacillus megaterium (MIC=100 μg/ml).
    • [Ref.2298215] Gram-negative bacteria: Agrobacterium tumefaciens Gembloux A (MIC≤1 µg/ml), Erwinia salicis NCPPB 2530 (MIC≤1 µg/ml), Escherichia coli NCTC 9001 (MIC≤1 µg/ml), Escherichia coli K514 (MIC=25-50 µg/ml), Pseudomonas syringae pv.tomato NCPPB 1105 (MIC≤1 µg/ml), Xanthomonas campestris pv. vesicatoria LMG 905 (MIC≥100 µg/ml);
    • Gram-positive bacteria: Bacillus megateriurn QMB 1551 (MIC=25-50 µg/ml), Bacillus alvei LMG 6922 (MIC=50-100 µg/ml),Micrococcus lysodeikticus LMG 4050 (MIC=25-50 µg/ml).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • Free

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • 4E81 resolved by X-ray.

• Predicted Structure

• Please click DRAMP02997_predicted_structure.pdb to download.

DRAMP02997

• • Function

  • Apidaecins have bactericidal activity; predominantly against Gram-negative bacteria. They seem to interfere with cell propagation.

• ·Literature 1

• • Title

  • Apidaecins: antibacterial peptides from honeybees.

• • Pubmed ID

  • 2676519

• • Reference

  • EMBO J. 1989 Aug;8(8):2387-2391.

• • Author

  • Casteels P, Ampe C, Jacobs F, Vaeck M, Tempst P.

• ·Literature 2

• • Title

  • Isolation and characterization of abaecin, a major antibacterial response peptide in the honeybee (Apis mellifera).

• • Pubmed ID

  • 2298215

• • Reference

  • Eur J Biochem. 1990 Jan 26;187(2):381-386.

• • Author

  • Casteels P, Ampe C, Riviere L, Van Damme J, Elicone C, Fleming M, Jacobs F, Tempst P.