General Information
-
DRAMP ID
- DRAMP03006
-
Peptide Name
- Defensin (Insects, animals)
-
Source
- Bombus pascuorum (Brown bumblebee)
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Family
- Belongs to the invertebrate defensin family (Type 1 subfamily)
-
Gene
- Not found
-
Sequence
- VTCDLLSIKGVAEHSACAANCLSMGKAGGRCENGICLCRKTTFKELWDKRF
-
Sequence Length
- 51
-
UniProt Entry
- P81462
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Antifungal
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Target Organism
-
- Gram-negative bacteria: Micrococcus luteus;
- Gram-negative bacteria: Escherichia coli D22.
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP03006.
Physicochemical Information
-
Formula
- C235H386N70O70S7
Absent Amino Acids
- PQY
Common Amino Acids
- CAGKL
Mass
- 5536.5
PI
- 8.65
Basic Residues
- 9
Acidic Residues
- 5
Hydrophobic Residues
- 17
Net Charge
- +4
-
Boman Index
- -71.64
Hydrophobicity
- -0.004
Aliphatic Index
- 74.71
Half Life
-
- Mammalian:100 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5875
Absorbance 280nm
- 117.5
Polar Residues
- 19
DRAMP03006
Comments Information
Function
- Antibacterial peptide against Gram-positive and Gram-negative bacteria and fungi.
Induction
- By bacterial infection.
Literature Information
- ·Literature 1
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Title
- Novel antibacterial peptides isolated from a European bumblebee, Bombus pascuorum (Hymenoptera, Apoidea).
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Pubmed ID
- 9219367
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Reference
- Insect Biochem Mol Biol. 1997 May;27(5):413-422.
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Author
- Rees JA, Moniatte M, Bulet P.