General Information
-
DRAMP ID
- DRAMP03008
-
Peptide Name
- Bombolitin I (insects, arthropods, invertebrates, animals)
-
Source
- Megabombus pennsylvanicus (Bumblebee)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- IKITTMLAKLGKVLAHV
-
Sequence Length
- 17
-
UniProt Entry
- P10521
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti Mammalian Cells
-
Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- [Ref.2578459] Hemolysis: ED50=4.0±0.05 µg/ml. Histamine release: ED50=16.3±0.5 µg/ml against guinea pig erythrocytes.
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP03008.
Physicochemical Information
-
Formula
- C85H154N22O20S
Absent Amino Acids
- CDEFNPQRSWY
Common Amino Acids
- KL
Mass
- 1836.35
PI
- 10.3
Basic Residues
- 4
Acidic Residues
- 0
Hydrophobic Residues
- 9
Net Charge
- +4
-
Boman Index
- 13.14
Hydrophobicity
- 1.035
Aliphatic Index
- 160.59
Half Life
-
- Mammalian:20 hour
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 3
DRAMP03008
Comments Information
Function
- Mast cell degranulating peptide. Has hemolytic activity.
Literature Information
- ·Literature 1
-
Title
- Bombolitins, a new class of mast cell degranulating peptides from the venom of the bumblebee Megabombus pennsylvanicus.
-
Pubmed ID
- 2578459
-
Reference
- J Biol Chem. 1985 Feb 10;260(3):1437-144.
-
Author
- Argiolas A, Pisano JJ.