General Information

    • DRAMP ID

    • DRAMP03009

    • Peptide Name

    • Bombolitin II (insects, arthropods, invertebrates, animals)

    • Source

    • Megabombus pennsylvanicus (Bumblebee)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • SKITDILAKLGKVLAHV

    • Sequence Length

    • 17

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti Mammalian Cells

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • [Ref.2578459] Hemolysis: ED50=3.9±0.06 µg/ml. Histamine release: ED50=15.8±0.5 µg/ml against guinea pig erythrocytes.

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03009 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03009.

Physicochemical Information

    • Formula

    • C83H148N22O22

    • Absent Amino Acids

    • CEFMNPQRWY

    • Common Amino Acids

    • KL

    • Mass

    • 1806.22

    • PI

    • 9.7

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +3

    • Boman Index

    • 1.24

    • Hydrophobicity

    • 0.712

    • Aliphatic Index

    • 160.59

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP03009

Comments Information

    • Function

    • Mast cell degranulating peptide. Has hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Bombolitins, a new class of mast cell degranulating peptides from the venom of the bumblebee Megabombus pennsylvanicus.

    • Reference

    • J Biol Chem. 1985 Feb 10;260(3):1437-144.

    • Author

    • Argiolas A, Pisano JJ.