General Information
-
DRAMP ID
- DRAMP03015
-
Peptide Name
- Bombolitin-8 (Insects, animals)
-
Source
- Bombus lapidarius (Red-tailed bumblebee) (Apis lapidaria)
-
Family
- Belongs to the MCD family Bombolitin subfamily
-
Gene
- Not found
-
Sequence
- LKLKSILGKLGVILSHLNK
-
Sequence Length
- 19
-
UniProt Entry
- P0CD69
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Antifungal
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Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP03015.
Physicochemical Information
-
Formula
- C97H176N26O23
Absent Amino Acids
- ACDEFMPQRTWY
Common Amino Acids
- L
Mass
- 2074.62
PI
- 10.48
Basic Residues
- 5
Acidic Residues
- 0
Hydrophobic Residues
- 9
Net Charge
- +5
-
Boman Index
- 4.98
Hydrophobicity
- 0.595
Aliphatic Index
- 179.47
Half Life
-
- Mammalian:5.5 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 5
DRAMP03015
Comments Information
Function
- Mast cell degranulating peptide. May also display antibacterial and antifungal activities (By similarity).
Tissue specificity
- Expressed by the venom gland.
Literature Information
- ·Literature 1
-
Title
- Mass spectrometry strategies for venom mapping and peptide sequencing from crude venoms: case applications with single arthropod specimen.
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Pubmed ID
- 16626777
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Reference
- Toxicon. 2006 May;47(6):676-687.
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Author
- Favreau P, Menin L, Michalet S, Perret F, Cheneval O, Stöcklin M, Bulet P, Stöcklin R.