• DRAMP ID

    • DRAMP03435
    • Peptide Name

    • Beta-defensin 17 (BD-17, RBD-17; Defensin, beta 17; Rodents, mammals, animals)
    • Source

    • Rattus norvegicus (Rat)
    • Family

    • Belongs to the beta-defensin family
    • Gene

    • Defb17
    • Sequence

    • KRSYPEYGSLDLRKECRMSKGHCKLQCSENEIRIAFCIRPGTHCCI
    • Sequence Length

    • 46
    • Protein Existence

    • Homology
    • Biological Activity

    • Antimicrobial, Antibacterial
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Bridge
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP03435 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP03435.
    • Formula

    • C226H369N71O66S7
    • Absent Amino Acids

    • VW
    • Common Amino Acids

    • C
    • Mass

    • 5361.27
    • PI

    • 8.89
    • Basic Residues

    • 11
    • Acidic Residues

    • 5
    • Hydrophobic Residues

    • 9
    • Net Charge

    • +6
    • Boman Index

    • -118.63
    • Hydrophobicity

    • -0.63
    • Aliphatic Index

    • 61.52
    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 3355
    • Absorbance 280nm

    • 74.56
    • Polar Residues

    • 17

DRAMP03435

DRAMP03435 chydropathy plot
    • Function Has antibacterial activity (By similarity).

    • PTM

    • Contains three disulfide bonds 16-44; 23-37; 27-45.
  • ·Literature 1
    • Title

    • Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.
    • Reference

    • Physiol Genomics. 2005 Sep 21;23(1):5-17.
    • Author

    • Patil AA, Cai Y, Sang Y, Blecha F, Zhang G.