• DRAMP ID

    • DRAMP03574
    • Peptide Name

    • LL-37(17-32)(C-terminal fragment of LL-37; Human, mammals, animals)
    • Source

    • Homo sapiens (Human)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • FKRIVQRIKDFLRNLV
    • Sequence Length

    • 16
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-, Anticancer
    • Target Organism

      • Gram-negative bacteria: Escherichia coli K12(MIC=20 µM).
      • Drug-resistant KBv cancer cells (LC50=30 µM), Drug-sensitive KB cancer cells (LC50=30 µM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Amidation
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bonds
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • To achieve selective membrane targeting, D-amino acids were incorporated into LL-37(17-32). The D-peptide showed similar antibacterial activity to the L-diastereomer, it lost toxicity to human cells.
    • Helical Wheel Diagram

    • DRAMP03574 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C95H161N29O21
    • Absent Amino Acids

    • ACEGHMPSTWY
    • Common Amino Acids

    • R
    • Mass

    • 2045.51
    • PI

    • 11.72
    • Basic Residues

    • 5
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 8
    • Net Charge

    • +4
    • Boman Index

    • -43.04
    • Hydrophobicity

    • -0.075
    • Aliphatic Index

    • 133.75
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 1

DRAMP03574

    • Antibacterial and anticancer assays found that LL-37(17-32) was more active than LL-37(13-37).

  • ·Literature 1
    • Title

    • Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region.
    • Reference

    • J Am Chem Soc. 2006 May 3;128(17):5776-5785.
    • Author

    • Li X, Li Y, Han H, Miller DW, Wang G.