General Information

    • DRAMP ID

    • DRAMP03637

    • Peptide Name

    • Thaumatin-like protein (Actc2)

    • Source

    • Actinidia chinensis (Kiwi) (Yangtao)

    • Family

    • Belongs to the thaumatin family

    • Gene

    • tlp

    • Sequence

    • ATFNFINNCPFTVWAAAVPG

    • Sequence Length

    • 20

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal, Antiviral

    • Target Organism

    • Botrytis cinerea, Coprinus comatus, Mycosphaerella arachidicola, Physalospora piricola, Candida albicans, Saccharomyces carlsbergensis, HIV-1 reverse transcriptase.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03637 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03637.

Physicochemical Information

    • Formula

    • C101H142N24O26S

    • Absent Amino Acids

    • DEHKLMQRSY

    • Common Amino Acids

    • A

    • Mass

    • 2140.44

    • PI

    • 5.56

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • 0

    • Boman Index

    • 8.67

    • Hydrophobicity

    • 0.73

    • Aliphatic Index

    • 68.5

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 289.47

    • Polar Residues

    • 7

DRAMP03637

DRAMP03637 chydropathy plot

Comments Information

    • Function

    • Has antifungal activity. Inhibits HIV-1 reverse transcriptase.

Literature Information

  • ·Literature 1

    • Title

    • Isolation of an antifungal thaumatin-like protein from kiwi fruits.

    • Reference

    • Phytochemistry. 2002 Sep;61(1):1-6.

    • Author

    • Wang H, Ng TB.
  • ·Literature 2

    • Title

    • Isolation and biochemical characterization of a thaumatin-like kiwi allergen.

    • Reference

    • J Allergy Clin Immunol. 2002 Nov;110(5):805-810.

    • Author

    • Gavrović-Jankulović M, ćIrković T, Vucković O, Atanasković-Marković M, Petersen A, Gojgić G, Burazer L, Jankov RM.
  • ·Literature 3

    • Title

    • IgE sensitization profiles toward green and gold kiwifruits differ among patients allergic to kiwifruit from 3 European countries.

    • Reference

    • J Allergy Clin Immunol. 2004 Nov;114(5):1169-1175.

    • Author

    • Bublin M, Mari A, Ebner C, Knulst A, Scheiner O, Hoffmann-Sommergruber K, Breiteneder H, Radauer C.