General Information

    • DRAMP ID

    • DRAMP03818

    • Peptide Name

    • cRW3 cationic antimicrobial peptide

    • Source

    • synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RRWFWR

    • Sequence Length

    • 6

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • No secondary structure

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03818 helical wheel diagram

    • PDB ID

    • 2OTQ resolved by NMR.

    • Predicted Structure

    • There is no predicted structure for DRAMP03818.

Physicochemical Information

    • Formula

    • C49H67N17O7

    • Absent Amino Acids

    • ACDEGHIKLMNPQSTVY

    • Common Amino Acids

    • R

    • Mass

    • 1006.18

    • PI

    • 12.3

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +3

    • Boman Index

    • -37.12

    • Hydrophobicity

    • -2.083

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 2200

    • Polar Residues

    • 0

DRAMP03818

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Structures of cyclic, antimicrobial peptides in a membrane-mimicking environment define requirements for activity.

    • Reference

    • J Pept Sci. 2008 Apr;14(4):524-527.

    • Author

    • Appelt C, Wessolowski A, Dathe M, Schmieder P.