General Information
-
DRAMP ID
- DRAMP04526
-
Peptide Name
- Parigidin-br1 (Cyclotides; Plants)
-
Source
- Palicourea rigida (Rubiaceae)
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Family
- Not found
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Gene
- Not found
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Sequence
- SCVFIPCITSLAGCSCKNKVCYYDGGSVPCGE
-
Sequence Length
- 32
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Insecticidal
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- Please click DRAMP04526_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C140H219N35O45S6
Absent Amino Acids
- HMQRW
Common Amino Acids
- C
Mass
- 3304.85
PI
- 5.78
Basic Residues
- 2
Acidic Residues
- 2
Hydrophobic Residues
- 8
Net Charge
- 0
-
Boman Index
- -6.61
Hydrophobicity
- 0.481
Aliphatic Index
- 66.88
Half Life
-
- Mammalian:1.9 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 3355
Absorbance 280nm
- 108.23
Polar Residues
- 18
DRAMP04526
Comments Information
Function
- Parigidin-br1 showes potent insecticidal activity against neonate larvae of Lepidoptera (Diatraea saccharalis), causing 60% mortality at a concentration of 1 µm but had no detectable antibacterial effects.
Literature Information
- ·Literature 1
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Title
- Identification and structural characterization of novel cyclotide with activity against an insect pest of sugar cane.
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Pubmed ID
- 22074926
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Reference
- J Biol Chem. 2012 Jan 2;287(1):134-147.
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Author
- Pinto MF, Fensterseifer IC, Migliolo L, Sousa DA, de Capdville G, Arboleda-Valencia JW, Colgrave ML, Craik DJ, Magalhães BS, Dias SC, Franco OL.