General Information

    • DRAMP ID

    • DRAMP04661

    • Peptide Name

    • HPA3NT3-F8A (HPA3NT3 peptide analogs)

    • Source

    • Helicobacter pylori

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FKRLKKLAKKIWNWK

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-gram+, Anti-gram-, Antifungal

    • Target Organism

      • [Ref.22982494] Gram-positive bacteria : Staphylococcus aureus(MIC=4 μM), Listeria monocytogenes(MIC=2 μM), Staphylococcus epidermidis(MIC=2-4 μM), Bacillus subtilis(MIC=4 μM);
      • Gram-negative bacteria : Escherichia coli(MIC=4 μM), Pseudomonas aeruginosa(MIC=2 μM), Primula vulgaris(MIC=4 μM), Salmonella typhimurium(MIC=2 μM);
      • Fungi : Candida albicans(MIC=8 μM), Trichosporon beigelii(MIC=16 μM), Aspergillus awamori(MIC=16 μM), Aspergillus flavus(MIC=16 μM), Aspergillus fumigatus(MIC=8 μM), Aspergillus parasiticus(MIC=8 μM)

    • Hemolytic Activity

      • [Ref.22982494] 4.6% hemolysis at 250 μM against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04661 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C98H159N27O17

    • Absent Amino Acids

    • CDEGHMPQSTVY

    • Common Amino Acids

    • K

    • Mass

    • 1987.51

    • PI

    • 11.43

    • Basic Residues

    • 7

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +7

    • Boman Index

    • -30.65

    • Hydrophobicity

    • -1.1

    • Aliphatic Index

    • 84.67

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 785.71

    • Polar Residues

    • 1

DRAMP04661

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Trichosporon beigelli, Aspergillus awamori, Aspergillus flavus, Aspergillus fumigatus, Aspergillus parasiticus

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial HPA3NT3 peptide analogs: Placement of aromatic rings and positive charges are key determinants for cell selectivity and mechanism of action.

    • Reference

    • Biochim Biophys Acta. 2013 Feb;1828(2):443-454. doi: 10.1016/j.bbamem.2012.09.005

    • Author

    • Lee JK, Park SC, Hahm KS, Park Y.