General Information
-
DRAMP ID
- DRAMP04662
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Peptide Name
- HPA3NT3-F1AF8A (HPA3NT3 peptide analogs)
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Source
- Helicobacter pylori
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Family
- Not found
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Gene
- Not found
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Sequence
- AKRLKKLAKKIWNWK
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Sequence Length
- 15
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UniProt Entry
- No entry found
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Protein Existence
- Not found
Activity Information
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Biological Activity
- Antimicrobial, Antibacterial, Anti-gram+, Anti-gram-, Antifungal
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Target Organism
-
- [Ref.22982494] Gram-positive bacteria : Staphylococcus aureus(MIC=16 μM), Listeria monocytogenes(MIC=2 μM), Staphylococcus epidermidis(MIC=16 μM), Bacillus subtilis(MIC=4 μM);
- Gram-negative bacteria : Escherichia coli(MIC=32 μM), Pseudomonas aeruginosa(MIC=2 μM), Primula vulgaris(MIC=4 μM), Salmonella typhimurium(MIC=2 μM);
- Fungi : Candida albicans(MIC=16 μM), Trichosporon beigelii(MIC=32 μM), Aspergillus awamori(MIC=16 μM), Aspergillus flavus(MIC=32 μM), Aspergillus fumigatus(MIC=4 μM), Aspergillus parasiticus(MIC=8 μM)
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Hemolytic Activity
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- [Ref.22982494] 0% hemolysis at 250 μM against human red blood cells
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
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Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
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PDB ID
- None
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Predicted Structure
- Please click DRAMP04662_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C92H155N27O17
Absent Amino Acids
- CDEFGHMPQSTVY
Common Amino Acids
- K
Mass
- 1911.41
PI
- 11.43
Basic Residues
- 7
Acidic Residues
- 0
Hydrophobic Residues
- 7
Net Charge
- +7
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Boman Index
- -31.82
Hydrophobicity
- -1.167
Aliphatic Index
- 91.33
Half Life
-
- Mammalian:4.4 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 11000
Absorbance 280nm
- 785.71
Polar Residues
- 1
DRAMP04662
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Trichosporon beigelli, Aspergillus awamori, Aspergillus flavus, Aspergillus fumigatus, Aspergillus parasiticus
Literature Information
- ·Literature 1
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Title
- Antimicrobial HPA3NT3 peptide analogs: Placement of aromatic rings and positive charges are key determinants for cell selectivity and mechanism of action.
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Pubmed ID
- 22982494
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Reference
- Biochim Biophys Acta. 2013 Feb;1828(2):443-454. doi: 10.1016/j.bbamem.2012.09.005
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Author
- Lee JK, Park SC, Hahm KS, Park Y.