General Information

    • DRAMP ID

    • DRAMP18253

    • Peptide Name

    • Piscicocin CS526(Bacteriocin)

    • Source

    • Carnobacterium piscicola CS526

    • Family

    • Belongs to the class IIa bacteriocin

    • Gene

    • Not found

    • Sequence

    • KYYGNGLSXNKKGXTVDWGTAIGIIGNNAAANXATGGAAGXNK

    • Sequence Length

    • 43

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

    • Gram-positive, Gram-negative

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • In this study, we found that piscicocin CS526, which possessed YGNGL sequence, had anti-Listeria activity typical of class IIa bacteriocins. Accordingly, the presence of Val7 within the YGNGV7 motif could not be a prerequisite for the antimicrobial activity of class IIa bacteriocins.

    • Helical Wheel Diagram

    • DRAMP18253 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18253.

Physicochemical Information

    • Formula

    • C164H252N50O50

    • Absent Amino Acids

    • CEFHMPQR

    • Common Amino Acids

    • G

    • Mass

    • 4241.49

    • PI

    • 9.7

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +3

    • Boman Index

    • -3497

    • Hydrophobicity

    • -0.372

    • Aliphatic Index

    • 59.3

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 8480

    • Absorbance 280nm

    • 201.9

    • Polar Residues

    • 21

DRAMP18253

DRAMP18253 chydropathy plot

Comments Information

    • The bacteriocin piscicocin CS526 was inactivated by proteolytic enzymes, was stable at 100 Celsius degree for 30 min, had a pH range of 2 to 8, and was active against Enterococcus, Listeria, Pediococcus, and Leuconostoc.

Literature Information

  • ·Literature 1

    • Title

    • Purification and characterization of a novel class IIa bacteriocin, piscicocin CS526, from surimi-associated Carnobacterium piscicola CS526.

    • Reference

    • Appl Environ Microbiol. 2005 Jan;71(1):554-7.

    • Author

    • Yamazaki K, Suzuki M, Kawai Y, Inoue N, Montville TJ.
  • ·Literature 2

    • Title

    • Mode of action of piscicocin CS526 produced by Carnobacterium piscicola CS526.

    • Reference

    • J Appl Microbiol. 2005;98(5):1146-51.

    • Author

    • Suzuki M, Yamamoto T, Kawai Y, Inoue N, Yamazaki K.