General Information

    • DRAMP ID

    • DRAMP18325

    • Peptide Name

    • delta-lysin I (Bacteriocin)

    • Source

    • Staphylococcus warneri RK

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • MAADIISTIGDLVKLIINTVKKFQK

    • Sequence Length

    • 25

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.18339450]Gram-positive bacteria:
        Target OrganismActivity
        Bacillus megaterium F04+
         Bacillus subtilis–
         Enterococcus faecalis V583–
         Listeria monocytogenes EGDe–
         Micrococcus luteus–
         Pediococcus acidilactici 583–
         Staphylococcus aureus 971–
         Staphylococcus chromogenes–
         Staphylococcus cohnii 898–
         Staphylococcus epidermidis 567-
         Staphylococcus haemolyticus 694-
         Staphylococcus hominis 373-
         Staphylococcus lentus 982-
        Staphylococcus lugdunensis 967-
         Staphylococcus saprophyticus 715-
         Staphylococcus warneri 447-
         Staphylococcus warneri RK(-);-
      • Gram-negative bacteria:
        Target OrganismActivity
        Enterobacter cloacae D03-
         Escherichia coli MG1655-
         Hafnia alvei-
         Klebsiella pneumoniae 0502083-
         Legionella bozemanii ATCC 33217+
         Legionella dumofii ATCC 33279+
         Legionella feeleii ATCC 35072+
         Legionella like bacteria (LLAP10)+
         Legionella longbeachae ATCC 33484+
         Legionella micdadei ATCC 33218+
         Legionella oakridgensis ATCC 33761+
         Legionella pneumophila Corby (sg1)+
         Legionella pneumophila Lens (sg1)+
         Legionella pneumophila Paris (sg1)+
         Legionella pneumophila ATCC 33155 (sg3)+
         Legionella pneumophila ATCC 33216 (sg5)+
         Legionella pneumophila ATCC 33215 (sg6)+
         Proteus mirabilis ATCC 35659-
         Pseudomonas aeruginosa DSMZ1128-
         Pseudomonas aeruginosa 910704-
         Salmonella typhimurium-

    • Hemolytic Activity

      • [Ref.18339450]10% hemolytic activity at 1.56 μM, 40% hemolytic activity at 6.25 μM, 62% hemolytic activity at 25 μM, 80% hemolytic activity at 50 μM against human erythrocytes

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18325 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18325.

Physicochemical Information

    • Formula

    • C126H219N31O35S

    • Absent Amino Acids

    • CEHPRWY

    • Common Amino Acids

    • I

    • Mass

    • 2760.37

    • PI

    • 9.52

    • Basic Residues

    • 4

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +2

    • Boman Index

    • -795

    • Hydrophobicity

    • 0.584

    • Aliphatic Index

    • 140.4

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP18325

DRAMP18325 chydropathy plot

Comments Information

    • Warnericin RK and delta-lysin I displayed the same antibacterial spectrum, which is almost restricted to the Legionella genus. Also, both peptides have a hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Characterization of anti-Legionella activity of warnericin RK and delta-lysin I from Staphylococcus warneri.

    • Reference

    • Peptides. 2008 Jun;29(6):978-84.

    • Author

    • Verdon J, Berjeaud JM, Lacombe C, H