General Information
-
DRAMP ID
- DRAMP18345
-
Peptide Name
- Tricyclic peptide RP 71955 (Bacteriocin)
-
Source
- Streptomyces sp. (strain SP9440)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- CLGIGSCNNFAGCGYAVVCFW
-
Sequence Length
- 21
-
UniProt Entry
- P37046
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Protein Existence
Activity Information
-
Biological Activity
- Antiviral, Anti-HIV, Antimicrobial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Beta strand
-
Structure Description
- An internal amide bond between the NH2 of C1 and the gamma-COOH of D9 was observed, as well as two disulfide bridges, one between C1 and C13 and one between C7 and C19.
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Helical Wheel Diagram
-
Predicted Structure
- There is no predicted structure for DRAMP18345.
Physicochemical Information
-
Formula
- C97H138N24O26S4
Absent Amino Acids
- DEHKMPQRT
Common Amino Acids
- CG
Mass
- 2184.55
PI
- 5.5
Basic Residues
- 0
Acidic Residues
- 0
Hydrophobic Residues
- 9
Net Charge
- 0
-
Boman Index
- 2189
Hydrophobicity
- 1.157
Aliphatic Index
- 74.29
Half Life
-
- Mammalian:1.2 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 7240
Absorbance 280nm
- 362
Polar Residues
- 12
DRAMP18345
Comments Information
Caution
- The isopeptide linked residue 9 is shown as Asn rather than Asp as mentioned in PubMed
Literature Information
- ·Literature 1
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Title
- Isolation of RP 71955, a new anti-HIV-1 peptide secondary metabolite.
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Pubmed ID
- 8270499
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Reference
- J Antibiot (Tokyo). 1993 Nov;46(11):1756-7.
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Author
- Helynck G, Dubertret C, Mayaux JF, Leboul J.