General Information

    • DRAMP ID

    • DRAMP18358

    • Peptide Name

    • Sh-lantibiotic-beta (bacteriocin)

    • Source

    • human skin bacterium, Staphylococcus hominis A9

    • Family

    • Belongs to the lantibiotic family.

    • Gene

    • Not found

    • Sequence

    • ATPTITTSSATCGGIIVAASAAQCPTLACSSRCGKRKK

    • Sequence Length

    • 38

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: S. aureus.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18358 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18358.

Physicochemical Information

    • Formula

    • C152H266N48O50S4

    • Absent Amino Acids

    • DEFHMNWY

    • Common Amino Acids

    • A

    • Mass

    • 3712.33

    • PI

    • 9.58

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +5

    • Boman Index

    • -4012

    • Hydrophobicity

    • 0.187

    • Aliphatic Index

    • 65.38

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 250

    • Absorbance 280nm

    • 6.58

    • Polar Residues

    • 18

DRAMP18358

DRAMP18358 chydropathy plot

Comments Information

    • Function

    • Active against S. aureus, but not commensal bacteria.

    • PTM

    • Four thioether bonds are proposed

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis

    • Reference

    • Sci Transl Med. 2017 Feb 22;9(378).

    • Author

    • Nakatsuji T, Chen TH, Narala S, Chun KA, Two AM, Yun T, Shafiq F, Kotol PF, Bouslimani A, Melnik AV, Latif H, Kim JN, Lockhart A, Artis K, David G, Taylor P, Streib J, Dorrestein PC, Grier A, Gill SR, Zengler K, Hata TR, Leung DY, Gallo RL