General Information
-
DRAMP ID
- DRAMP18379
-
Peptide Name
- Acipensin 2 (Ac2)
-
Source
- Leukocytes; the Russian Sturgeon, Acipenser gueldenstaedtii
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Family
- Not found
-
Gene
- Not found
-
Sequence
- SGRGKTGGKARAKAKTRSSRAGLQFPVGRVHRLLR
-
Sequence Length
- 35
-
UniProt Entry
- No entry found
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Protein Existence
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Antifungal
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Target Organism
- Active against E. coli ML35p (MIC 0.3 uM), L. monocytogenes EGD (MIC 1.0 uM), MRSA ATCC 33591 (MIC 0.6 uM), C. albicans 820 (MIC 0.9 uM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP18379.
Physicochemical Information
-
Formula
- C160H281N63O41
Absent Amino Acids
- CDEIMNWY
Common Amino Acids
- R
Mass
- 3761.4
PI
- 12.78
Basic Residues
- 12
Acidic Residues
- 0
Hydrophobic Residues
- 10
Net Charge
- +12
-
Boman Index
- -11348
Hydrophobicity
- -0.883
Aliphatic Index
- 59.72
Half Life
-
- Mammalian:1.9 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 11
DRAMP18379
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
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Title
- Acipensins - Novel Antimicrobial Peptides from Leukocytes of the Russian Sturgeon Acipenser gueldenstaedtii.
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Pubmed ID
- 25558400
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Reference
- Acta Naturae. 2014 Oct;6(4):99-109.
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Author
- Shamova OV, Orlov DS, Balandin SV, Shramova EI, Tsvetkova EV, Panteleev PV, Leonova YF, Tagaev AA, Kokryakov VN, Ovchinnikova TV.