General Information

    • DRAMP ID

    • DRAMP18381

    • Peptide Name

    • H4-(86-100) (histone-derived)

    • Source

    • rat

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • VVYALKRNGRTLYGF

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • Active against E. coli (LD90 6.68 ug/ml), P. aeruginosa (LD90 4.8 ug/ml), B. subtilis (LD90 17 ug/ml), and S. aureus (14.7 ug.ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18381 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18381.

Physicochemical Information

    • Formula

    • C82H129N23O20

    • Absent Amino Acids

    • CDEHIMPQSW

    • Common Amino Acids

    • GLRVY

    • Mass

    • 1757.07

    • PI

    • 10.28

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +3

    • Boman Index

    • -2029

    • Hydrophobicity

    • 0.007

    • Aliphatic Index

    • 97.33

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 2980

    • Absorbance 280nm

    • 212.86

    • Polar Residues

    • 6

DRAMP18381

Comments Information

    • Fuction

    • ATP can enahnce its activity, implying its involvement in inhibiting the DNA gyrase activity.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial effects of H4-(86-100), histogranin and related compounds--possible involvement of DNA gyrase.

    • Reference

    • FEBS J. 2008 Nov;275(21):5286-97.

    • Author

    • Lemaire S, Trinh TT, Le HT, Tang SC, Hincke M, Wellman-Labadie O, Ziai S.