General Information

    • DRAMP ID

    • DRAMP18382

    • Peptide Name

    • HNr (histone-derived)

    • Source

    • rat

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • VVYTLKRNGRTLYGF

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • Active against E. coli (LD90 10.3 ug/ml), P. aeruginosa LD90 8.7 ug/ml), and B. subtilis (LD90 14 ug/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18382 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18382.

Physicochemical Information

    • Formula

    • C83H131N23O21

    • Absent Amino Acids

    • ACDEHIMPQSW

    • Common Amino Acids

    • GLRTVY

    • Mass

    • 1787.09

    • PI

    • 10.28

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +3

    • Boman Index

    • -2467

    • Hydrophobicity

    • -0.16

    • Aliphatic Index

    • 90.67

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 2980

    • Absorbance 280nm

    • 212.86

    • Polar Residues

    • 7

DRAMP18382

Comments Information

    • Fuction

    • ATP can enahnce its activity, implying its involvement in inhibiting the DNA gyrase activity.

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial effects of H4-(86-100), histogranin and related compounds--possible involvement of DNA gyrase.

    • Reference

    • FEBS J. 2008 Nov;275(21):5286-97.

    • Author

    • Lemaire S, Trinh TT, Le HT, Tang SC, Hincke M, Wellman-Labadie O, Ziai S.