General Information

    • DRAMP ID

    • DRAMP18397

    • Peptide Name

    • Um4 (scorpions, arachnids, Chelicerata, arthropods, invertebrates, animals)

    • Source

    • Urodacus manicatus

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FFSALLSGIKSLF

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • Active against M. luteus (MIC 8 uM), E. coli (8 uM), S. aureus (15 uM), L. grayi (15 uM), L. fleischmannii (MIC 4 uM), and L. monocytogenes (MIC 8 uM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP18397 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP18397.

Physicochemical Information

    • Formula

    • C71H108N14O17

    • Absent Amino Acids

    • CDEHMNPQRTVWY

    • Common Amino Acids

    • FLS

    • Mass

    • 1429.72

    • PI

    • 8.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +1

    • Boman Index

    • 1562

    • Hydrophobicity

    • 1.492

    • Aliphatic Index

    • 127.69

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP18397

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Bioactivity of Natural and Engineered Antimicrobial Peptides from Venom of the Scorpions Urodacus yaschenkoi and U. manicatus

    • Reference

    • Toxins (Basel). 2017 Jan 6;9, 22. doi: 10.3390/toxins9010022.

    • Author

    • Luna-Ramirez K, Tonk M, Rahnamaeian M, Vilcinskas A.