• • DRAMP ID

  • DRAMP21577

• • Peptide Name

  • LP1

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • WWVAARAARR

• • Sequence Length

  • 10

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic form

• • SMILES

  • CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O

• • Biological Activity

  • Antimicrobial, Antifungal

• • Target Organism

  • • [Ref.28073163] Gram-positive bacteria:

      Target Organism	Activity
      Bacillus megaterium ATCC 14581	IC50 = 237 μM, MIC > 20 μM
      Staphylococcus aureus ATCC 6538	IC50 = 188 μM, MIC > 20 μM
      Enterococcus faecalis ATCC 29212	IC50 = 134 μM, MIC > 20 μM

    • Gram-negative bacteria:

      Target Organism	Activity
      Escherichia coli ATCC 700926	IC50 = 805 μM, MIC > 20 μM

    • Fungi:

      Target Organism	Activity
      Candida albicans 002 ATCC 64385	IC50 = 20 μM, MIC > 20 μM
      C. albicans 004 ATCC MYA-2876	IC50 = 20 μM, MIC > 20 μM

• • Hemolytic Activity

  • • [Ref.28073163] HC50 = 1810 μM against human red blood cells. Note: HC50 is the half-maximal hemolytic concentration.

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • ①Random-coil conformation. ②1.9% α-helix and 22.1% β-strand in 20 mM potassium phosphate buffer; 0.6% α-helix and 37.2% β-strand in 20 mM potassium ph

• • Structure Description

  • LP1 appears to adopt a random-coli conformation.

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP21577.

DRAMP21577

• • Function

  • Potential antifungal activity against Candida albicans.

• ·Literature 1

• • Title

  • Hydrocarbon-stapled lipopeptides exhibit selective antimicrobial activity

• • Pubmed ID

  • 28073163

• • Reference

  • Biopolymers. 2017 May;108(3). doi: 10.1002/bip.23006.

• • Author

  • Zachary B Jenner, Christopher M Crittenden, Martín Gonzalez, Jennifer S Brodbelt, Kerry A Bruns