General Information

    • DRAMP ID

    • DRAMP21577

    • Peptide Name

    • LP1

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • WWVAARAARR

    • Sequence Length

    • 10

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • [Ref.28073163] Gram-positive bacteria: Bacillus megaterium ATCC 14581 (IC50 = 237 μM, MIC > 20 μM), Staphylococcus aureus ATCC 6538 (IC50 = 188 μM, MIC > 20 μM), Enterococcus faecalis ATCC 29212 (IC50 = 134 μM, MIC > 20 μM);
      • Gram-negative bacteria: Escherichia coli ATCC 700926 (IC50 = 805 μM, MIC > 20 μM);
      • Fungi: Candida albicans 002 ATCC 64385 (IC50 = 20 μM, MIC > 20 μM), C. albicans 004 ATCC MYA-2876 (IC50 = 20 μM, MIC > 20 μM).

    • Hemolytic Activity

      • [Ref.28073163] HC50 = 1810 μM against human red blood cells. Note: HC50 is the half-maximal hemolytic concentration.

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • ①Random-coil conformation. ②1.9% α-helix and 22.1% β-strand in 20 mM potassium phosphate buffer; 0.6% α-helix and 37.2% β-strand in 20 mM potassium ph

    • Structure Description

    • LP1 appears to adopt a random-coli conformation.

    • Helical Wheel Diagram

    • DRAMP21577 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21577.

Physicochemical Information

    • Formula

    • C₅₇H₈₆N₂₁O₁₁

    • Absent Amino Acids

    • CDEFGHIKLMNPQSTY

    • Common Amino Acids

    • A

    • Mass

    • 1242.45

    • PI

    • 12.3

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +3

    • Boman Index

    • -2882

    • Hydrophobicity

    • -0.39

    • Aliphatic Index

    • 69

    • Half Life

      • Mammalian:2.8 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 1222.22

    • Polar Residues

    • 0

DRAMP21577

Comments Information

    • Function

    • Potential antifungal activity against Candida albicans.

Literature Information

  • ·Literature 1

    • Title

    • Hydrocarbon-stapled lipopeptides exhibit selective antimicrobial activity

    • Reference

    • Biopolymers. 2017 May;108(3). doi: 10.1002/bip.23006.

    • Author

    • Zachary B Jenner, Christopher M Crittenden, Martín Gonzalez, Jennifer S Brodbelt, Kerry A Bruns