General Information

    • DRAMP ID

    • DRAMP29136

    • Peptide Name

    • XT-7 [N16K]

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • N/A

    • Sequence

    • GLLGPLLKIAAKVGSKLL

    • Sequence Length

    • 18

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.23094651]Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=6.3 µM).
      • [Ref.18554256]Gram-negative bacteria:Escherichia coli ATCC 25726(MIC=12.5 µM);
      • Gram-positive bactria:Staphylococcus aureus ATCC 25923(MIC=3 µM);
      • Fungi:Candida albicans ATCC 900280(MIC=12.5 µM);
      • Cancer: human hepatoma‐derived cells HepG2 (LC50=22 µM).

    • Hemolytic Activity

      • [Ref.23094651]50% hemolysis against rat erythrocytes at 142 µM.
      • [Ref.18554256]Hemolysis against human erythrocytes (LC50=80 µM).

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • liposomes

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP29136 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29136.

Physicochemical Information

    • Formula

    • C85H155N21O20

    • Absent Amino Acids

    • CDEFHMNQRTWY

    • Common Amino Acids

    • L

    • Mass

    • 1791.29

    • PI

    • 10.3

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +3

    • Boman Index

    • 2487

    • Hydrophobicity

    • 1.1

    • Aliphatic Index

    • 178.89

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP29136

DRAMP29136 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.Antifungal activity against Candida albicans.

Literature Information

  • ·Literature 1

    • Title

    • Improving the selectivity of antimicrobial peptides from anuran skin.

    • Reference

    • J Chem Inf Model. 2012 Dec 21;52(12):3341-51.

    • Author

    • Kamech N, Vukičević D, Ladram A, Piesse C, Vasseur J, Bojović V, Simunić J, Juretić D.
  • ·Literature 2

    • Title

    • Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7.

    • Reference

    • Chem Biol Drug Des. 2008 Jul;72(1):58-64.

    • Author

    • Conlon JM, Galadari S, Raza H, Condamine E.