General Information

    • DRAMP ID

    • DRAMP29201

    • Peptide Name

    • SARS-CoV-2 HR1P

    • Source

    • Synthetic construct

    • Family

    • Belongs to the betacoronaviruses spike protein family.

    • Gene

    • S

    • Sequence

    • ANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQ

    • Sequence Length

    • 42

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral(SARS-CoV-2)

    • Target Organism

      • [Ref.32047258]Virus:SARS-CoV-2(No inhibition of cell-cell fusion up to 40 µM in Huh-7 cells,No inhibition of infection up to 40 µM in 293T/ACE2 cells)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP29201 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29201.

Physicochemical Information

    • Formula

    • C187H314N56O65

    • Absent Amino Acids

    • CEHMPRWY

    • Common Amino Acids

    • AQ

    • Mass

    • 4386.89

    • PI

    • 8.54

    • Basic Residues

    • 3

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 17

    • Net Charge

    • +1

    • Boman Index

    • -6039

    • Hydrophobicity

    • -0.219

    • Aliphatic Index

    • 100

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 14

DRAMP29201

DRAMP29201 chydropathy plot

Comments Information

    • Mechanism of action

    • The peptide acted as a fusion inhibitor which against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection.

Literature Information

  • ·Literature 1

    • Title

    • Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein.

    • Reference

    • Cell Mol Immunol. 2020 Jul;17(7):765-767.

    • Author

    • Xia S, Zhu Y, Liu M, Lan Q, Xu W, Wu Y, Ying T, Liu S, Shi Z, Jiang S, Lu L.