General Information
-
DRAMP ID
- DRAMP29228
-
Peptide Name
- MERS-LP
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
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Sequence
- SLTQINTTLLDLTYEMLSLQQVVKALNESYIDLKEL
-
Sequence Length
- 36
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antiviral(SARS-CoV-2)
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Target Organism
-
- [Ref.34344868]Virus:
- SARS-CoV-2:inhibition of SARS-CoV-2 S protein-mediated cell-cell fusion(IC50=102.9±7.2 nM);inhibition of SARS-CoV-2 pseudovirus infection in Huh-7 cells(IC50=5046±905.2 nM);
- SARS-CoV-2 D614G:inhibition of S protein-mediated cell-cell fusion(IC50=79.1±9.8 nM);inhibition of pseudovirus infection in Huh-7 cells(IC50>25000 nM);
- SARS-CoV:inhibition of pseudovirus infection in Huh-7 cells(IC50>25000 nM);
- MERS-CoV:inhibition of pseudovirus infection in Huh-7 cells(IC50=82.9±8.6 nM);
- HCoV-NL63:inhibition of pseudovirus infection in Huh-7 cells(IC50>25000 nM);
- HCoV-229E:inhibition of pseudovirus infection in Huh-7 cells(IC50>25000 nM).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- liposomes
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- PEG8-K(Chol)
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- 8% α-helicity in phosphate-buffered saline (PBS; pH 7.2) with a final concentration of 10 μM and incubated at 37°C
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP29228.
Physicochemical Information
-
Formula
- C185H307N43O61S
Absent Amino Acids
- CFGHPRW
Common Amino Acids
- L
Mass
- 4141.78
PI
- 4.18
Basic Residues
- 2
Acidic Residues
- 5
Hydrophobic Residues
- 14
Net Charge
- -3
-
Boman Index
- -3327
Hydrophobicity
- 0.131
Aliphatic Index
- 138.06
Half Life
-
- Mammalian:1.9 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 2980
Absorbance 280nm
- 85.14
Polar Residues
- 11
DRAMP29228
Comments Information
The peptide is a fusion inhibitor against SARS-CoV-2.
Literature Information
- ·Literature 1
-
Title
- SARS-CoV-2-derived fusion inhibitor lipopeptides exhibit highly potent and broad-spectrum activity against divergent human coronaviruses.
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Pubmed ID
- 34344868
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Reference
- Signal Transduct Target Ther. 2021 Aug 3;6(1):294.
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Author
- Zhu Y, Yu D, Hu Y, Wu T, Chong H, He Y.