General Information
-
DRAMP ID
- DRAMP29949
-
Peptide Name
- BmKDfsin3
-
Source
- Mesobuthus martensii Karsch
-
Family
- Flaviviridae
-
Gene
- Not found
-
Sequence
- GFGCPFNQGKCHRHCRSIRRRGGYCDGFLKQRCVCYRK
-
Sequence Length
- 38
-
UniProt Entry
- A0A384E0Y8
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antiviral
-
Target Organism
-
- [Ref.31963532]Hepatitis C virus (HCV): inhibition of viral replication in Huh7.5.1 cells(IC50=3.35±1.1 µM).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- [Ref.31963532]Human hepatocellular carcinoma Huh-7.5.1 cells: CC50=60.63±1.36 µM.
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Cyclic
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- Disulfide bonds between Cys4 and Cys25, Cys11 and Cys33, Cys15 and Cys35.
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP29949.
Physicochemical Information
-
Formula
- C190H299N69O47S6
Absent Amino Acids
- AEMTW
Common Amino Acids
- R
Mass
- 4494.26
PI
- 10
Basic Residues
- 12
Acidic Residues
- 1
Hydrophobic Residues
- 6
Net Charge
- +11
-
Boman Index
- -12439
Hydrophobicity
- -0.924
Aliphatic Index
- 28.16
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 3355
Absorbance 280nm
- 90.68
Polar Residues
- 16
DRAMP29949
![DRAMP29949 chydropathy plot](http://dramp.cpu-bioinfor.org/tmp/all_info_png/pepwindow_DRAMP29949.1.png)
Comments Information
Mechanism
- BmKDfsin3 is revealed to enter into cells. Using an upstream MyD88 dimerization inhibitor ST2345 or kinase IRAK-1/4 inhibitor I, the inhibition of p38 activation represses HCV replication in vitro.
Literature Information
- ·Literature 1
-
Title
- Inhibitory Activity of a Scorpion Defensin BmKDfsin3 against Hepatitis C Virus.
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Pubmed ID
- 31963532
-
Reference
- Antibiotics (Basel). 2020 Jan 17;9(1):33.
-
Author
- Cheng Y, Sun F, Li S, Gao M, Wang L, Sarhan M, Abdel-Rahman MA, Li W, Kwok HF, Wu Y, Cao Z.