General Information
-
DRAMP ID
- DRAMP29951
-
Peptide Name
- NC-783
-
Source
- Synthetic construct
-
Family
- Paramyxoviridae
-
Gene
- Not found
-
Sequence
- KRRGGGKLLKLLLKLLLKLLKC
-
Sequence Length
- 22
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antiviral
-
Target Organism
-
- [Ref.32124885]Respiratory syncytial virus (RSV):inhibition of viral infection in the MA-104 cell(IC50=0.04mg/ml).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- [Ref.32124885]MA-104 cells:CC50= 0.04 ± 0.01 mg/ml.
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP29951.
Physicochemical Information
-
Formula
- C117H222N34O23S
Absent Amino Acids
- ADEFHIMNPQSTVWY
Common Amino Acids
- L
Mass
- 2505.32
PI
- 11.27
Basic Residues
- 8
Acidic Residues
- 0
Hydrophobic Residues
- 10
Net Charge
- +8
-
Boman Index
- -984
Hydrophobicity
- 0.314
Aliphatic Index
- 177.27
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 4
DRAMP29951
![DRAMP29951 chydropathy plot](http://dramp.cpu-bioinfor.org/tmp/all_info_png/pepwindow_DRAMP29951.1.png)
Comments Information
Mechanism
- It is likely that these peptides exert anti-RSV activity through a combination of two mechanisms
Literature Information
- ·Literature 1
-
Title
- Linear and dendrimeric antiviral peptides: design, chemical synthesis and activity against human respiratory syncytial virus.
-
Pubmed ID
- 32124885
-
Reference
- J Mater Chem B. 2020 Apr 1;8(13):2607-2617
-
Author
- Kozhikhova KV, Shilovskiy IP, Shatilov AA, Timofeeva AV, Turetskiy EA, Vishniakova LI, Nikolskii AA, Barvinskaya ED, Karthikeyan S, Smirnov VV, Kudlay DA, Andreev SM, Khaitov MR