General Information
-
DRAMP ID
- DRAMP29952
-
Peptide Name
- GI-20D
-
Source
- Synthetic construct(derived from LL-37)
-
Family
- Filoviridae
-
Gene
- Not found
-
Sequence
- gikefkrivqrikdflrnlv
-
Sequence Length
- 20
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antiviral
-
Target Organism
-
- [Ref.32252021]Ebola Virus(EBOV):inhibition of viral infection in Hela cells(IC50=0.99 µM);inhibition of viral infection in primary macrophages(IC50=2.2 µM).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- No cytotoxicity information or data found in the reference(s) presented in this entry
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- D
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP29952.
Physicochemical Information
-
Formula
- H-38O-19
Absent Amino Acids
- ACDEFGHIKLMNPQRST
Common Amino Acids
- ACDEFGHIK
Mass
- 2473.01
PI
- 11
Basic Residues
- 0
Acidic Residues
- 0
Hydrophobic Residues
- 0
Net Charge
- 0
-
Boman Index
- 0
Hydrophobicity
- 0
Aliphatic Index
- 0
Half Life
-
- Mammalian:
- Yeast:
- E.coli:
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 0
DRAMP29952
![DRAMP29952 chydropathy plot](http://dramp.cpu-bioinfor.org/tmp/all_info_png/pepwindow_DRAMP29952.1.png)
Comments Information
Mechanism
- Act as CatB inhibitors to block the endosomal processing of EBOV GP, thus preventing virus entry.
Literature Information
- ·Literature 1
-
Title
- Engineered Human Cathelicidin Antimicrobial Peptides Inhibit Ebola Virus Infection.
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Pubmed ID
- 32252021
-
Reference
- iScience. 2020 Apr 24;23(4):100999.
-
Author
- Yu Y, Cooper CL, Wang G, Morwitzer MJ, Kota K, Tran JP, Bradfute SB, Liu Y, Shao J, Zhang AK, Luo LG, Reid SP, Hinrichs SH, Su K.