General Information

    • DRAMP ID

    • DRAMP29953

    • Peptide Name

    • 17BIPHE2

    • Source

    • Synthetic construct(derived from LL-37)

    • Family

    • Filoviridae

    • Gene

    • Not found

    • Sequence

    • GXKRlVQRlKDXlRNLV

    • Sequence Length

    • 17

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

      • [Ref.32252021]Ebola Virus(EBOV):inhibition of viral infection in Hela cells(IC50=0.71 µM);inhibition of viral infection in primary macrophages(IC50=5.6 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • No cytotoxicity information or data found in the reference(s) presented in this entry

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • The 'X' at position 2 and 12 indicates biphenylalanine.

    • Stereochemistry

    • Mixed(D-Leu5, 9, 13)

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP29953 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29953.

Physicochemical Information

    • Formula

    • C61H103N25O12

    • Absent Amino Acids

    • ACEFHIMPSTWY

    • Common Amino Acids

    • R

    • Mass

    • 2030.86

    • PI

    • 11.72

    • Basic Residues

    • 5

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 3

    • Net Charge

    • +4

    • Boman Index

    • -6282

    • Hydrophobicity

    • -1.177

    • Aliphatic Index

    • 57.06

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP29953

Comments Information

    • Mechanism

    • Act as CatB inhibitors to block the endosomal processing of EBOV GP, thus preventing virus entry.

Literature Information

  • ·Literature 1

    • Title

    • Engineered Human Cathelicidin Antimicrobial Peptides Inhibit Ebola Virus Infection.

    • Reference

    • iScience. 2020 Apr 24;23(4):100999.

    • Author

    • Yu Y, Cooper CL, Wang G, Morwitzer MJ, Kota K, Tran JP, Bradfute SB, Liu Y, Shao J, Zhang AK, Luo LG, Reid SP, Hinrichs SH, Su K.