General Information
-
DRAMP ID
- DRAMP29953
-
Peptide Name
- 17BIPHE2
-
Source
- Synthetic construct(derived from LL-37)
-
Family
- Filoviridae
-
Gene
- Not found
-
Sequence
- GXKRlVQRlKDXlRNLV
-
Sequence Length
- 17
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antiviral
-
Target Organism
-
- [Ref.32252021]Ebola Virus(EBOV):inhibition of viral infection in Hela cells(IC50=0.71 µM);inhibition of viral infection in primary macrophages(IC50=5.6 µM).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- No cytotoxicity information or data found in the reference(s) presented in this entry
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- The 'X' at position 2 and 12 indicates biphenylalanine.
-
Stereochemistry
- Mixed(D-Leu5, 9, 13)
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP29953.
Physicochemical Information
-
Formula
- C61H103N25O12
Absent Amino Acids
- ACEFHIMPSTWY
Common Amino Acids
- R
Mass
- 2030.86
PI
- 11.72
Basic Residues
- 5
Acidic Residues
- 1
Hydrophobic Residues
- 3
Net Charge
- +4
-
Boman Index
- -6282
Hydrophobicity
- -1.177
Aliphatic Index
- 57.06
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 2
DRAMP29953
Comments Information
Mechanism
- Act as CatB inhibitors to block the endosomal processing of EBOV GP, thus preventing virus entry.
Literature Information
- ·Literature 1
-
Title
- Engineered Human Cathelicidin Antimicrobial Peptides Inhibit Ebola Virus Infection.
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Pubmed ID
- 32252021
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Reference
- iScience. 2020 Apr 24;23(4):100999.
-
Author
- Yu Y, Cooper CL, Wang G, Morwitzer MJ, Kota K, Tran JP, Bradfute SB, Liu Y, Shao J, Zhang AK, Luo LG, Reid SP, Hinrichs SH, Su K.