General Information

    • DRAMP ID

    • DRAMP29957

    • Peptide Name

    • U4

    • Source

    • Synthetic construct

    • Family

    • Orthomyxoviridae

    • Gene

    • Not found

    • Sequence

    • FINGRWDSQCHRFSNGAIACA

    • Sequence Length

    • 21

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

      • [Ref.35259078]influenza A virus(H1N1): inhibition of viral replication in MDCK cells(IC50=6.6 μg/ml);

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • No cytotoxicity information or data found in the reference(s) presented in this entry

    • Binding Target

    • HA

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP29957 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29957.

Physicochemical Information

    • Formula

    • C101H149N33O29S2

    • Absent Amino Acids

    • EKLMPTVY

    • Common Amino Acids

    • A

    • Mass

    • 2353.62

    • PI

    • 8.08

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +2

    • Boman Index

    • -4084

    • Hydrophobicity

    • -0.214

    • Aliphatic Index

    • 51.43

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5625

    • Absorbance 280nm

    • 281.25

    • Polar Residues

    • 8

DRAMP29957

DRAMP29957 chydropathy plot

Comments Information

    • Mechanism

    • Bind to the HA stem of group 1 influenza A virus.

Literature Information

  • ·Literature 1

    • Title

    • Fusion-inhibition peptide broadly inhibits influenza virus and SARS-CoV-2, including Delta and Omicron variants.

    • Reference

    • Emerg Microbes Infect. 2022 Dec;11(1):926-937.

    • Author

    • Zhao H, Meng X, Peng Z, Lam H, Zhang C, Zhou X, Chan JF, Kao RYT, To KK, Yuen KY.