General Information
-
DRAMP ID
- DRAMP29957
-
Peptide Name
- U4
-
Source
- Synthetic construct
-
Family
- Orthomyxoviridae
-
Gene
- Not found
-
Sequence
- FINGRWDSQCHRFSNGAIACA
-
Sequence Length
- 21
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antiviral
-
Target Organism
-
- [Ref.35259078]influenza A virus(H1N1): inhibition of viral replication in MDCK cells(IC50=6.6 μg/ml);
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- No cytotoxicity information or data found in the reference(s) presented in this entry
-
Binding Target
- HA
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP29957.
Physicochemical Information
-
Formula
- C101H149N33O29S2
Absent Amino Acids
- EKLMPTVY
Common Amino Acids
- A
Mass
- 2353.62
PI
- 8.08
Basic Residues
- 3
Acidic Residues
- 1
Hydrophobic Residues
- 8
Net Charge
- +2
-
Boman Index
- -4084
Hydrophobicity
- -0.214
Aliphatic Index
- 51.43
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 5625
Absorbance 280nm
- 281.25
Polar Residues
- 8
DRAMP29957
![DRAMP29957 chydropathy plot](http://dramp.cpu-bioinfor.org/tmp/all_info_png/pepwindow_DRAMP29957.1.png)
Comments Information
Mechanism
- Bind to the HA stem of group 1 influenza A virus.
Literature Information
- ·Literature 1
-
Title
- Fusion-inhibition peptide broadly inhibits influenza virus and SARS-CoV-2, including Delta and Omicron variants.
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Pubmed ID
- 35259078
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Reference
- Emerg Microbes Infect. 2022 Dec;11(1):926-937.
-
Author
- Zhao H, Meng X, Peng Z, Lam H, Zhang C, Zhou X, Chan JF, Kao RYT, To KK, Yuen KY.